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2016年10月3日

8190:「ベル現象を伴う開閉瞼と意図的な垂直眼球運動におけるヒトの脳の機能的な反応」

8190:「ベル現象を伴う開閉瞼と意図的な垂直眼球運動におけるヒトの脳の機能的な反応」::オンライン別刷になりました。https://www.jsTAGSe.jst.go.jp/article/tjem/240/2/240_141/_pdf

「ベル現象を伴う開閉瞼と意図的な垂直眼球運動におけるヒトの脳の機能的な反応」は私たちの研究論文ですが、これがTJEMに9月21日にアクセプトになり、そのgally proof(ゲラ原稿)が早くも送られてきました。

 有力な数誌に投稿するも、なかなか落ち着きどころが決まらず、難産であった論文ですが、筆頭著者の鈴木幸久君が情熱をもって時間もかけ、この論文を世に出してくれたことに喜びと誇りを感じています。眼瞼痙攣の治療の研究者としても、ぶれのない良い取り組みが出来ました。

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この雑誌のインパクトファクターは1,283としっかりした雑誌です。採択率は18%、投稿論文数(646編)の79%は海外からの投稿だそうです。基礎医学としても今後に残るしっかりした仕事が残せたと自負しています。

要旨での結論は、ベル現象に特有な活性化部位はなく、ベル現象は単なる反射運動だから意図的な上下の眼球運動で活性化される前頭眼野を活性化しない、ということです。

Tohoku J. Exp. Med., 2016, ###, 00-00

Received July 25, 2016; revised and accepted September 21, 2016.
Published online ####, 2016; doi: 10.1620/tjem.###.000.

Correspondence: Yukihisa Suzuki, M.D., Ph.D., Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Graduated School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. e-mail: suzuki@f8.dion.ne.jp

Cerebral Functional Response during Eyelid Opening/Closing with Bell’s Phenomenon and Volitional Vertical Eye Movements in Humans

Yukihisa Suzuki,1, 2, 3 Motohiro Kiyosawa,1,4 Kiichi Ishiwata,2, 5 Keiichi Oda2, 6 and Kenji Ishii2

Bell’s phenomenon is a physiological phenomenon wherein the eye ball involuntarily rolls upward during eyelid closing. Although this phenomenon occurs in healthy individuals, the neural mechanism related to Bell’s phenomenon has not yet been identified. We aimed to investigate the brain regions relevant to Bell’s phenomenon and volitional eye movement using [15O] H2O and positron emission tomography (PET). We measured regional cerebral blood flow (rCBF) in 8 normal subjects under 3 conditions: at rest with eyes closed, during opening and closing of the eyelids in response to sound stimuli (lid opening/closing), and during vertical movement of the eyes with lids closed in response to sound stimuli (volitional eye movement). The supplementary motor area (SMA) proper, right superior temporal gyrus, right insular cortex and left angular gyrus were activated during lid opening/closing. The right frontal eye field (FEF), pre-SMA, left primary motor area, right angular gyrus, and SMA proper were activated during volitional eye movement. The SMA proper was active during both tasks, while the FEF and pre-SMA were active during volitional eye movement, but not during eyelid opening/closing. A comparison of activation during volitional eye movements and lid opening/closing tasks revealed a relative increase in rCBF in the FEF. There were no areas that are activated in relation to Bell’s phenomenon. In conclusion, activation in the FEF mainly occurs during volitional eye movement. Since Bell’s phenomenon is a reflexive eye movement, the FEF is scarcely concerned in Bell’s phenomenon.

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