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2016年8月6日

8023:視野回復に伴う第一次視覚領の糖代謝の回復

慶祝:
東北実験医学雑誌(TOHOKU UNIVERSITY MEDICAL PRESS発行の英文誌)の4月号(Vol. 238, No. 4 April, 2016 (articles ahead of print) )に私たちの論文:
「半盲患者の視野回復は、視覚領皮質におけるぶどう糖代謝量に伴う」
が掲載されました。この雑誌の2014年のImpact Factorは、1.351で、地方大学が発行する英文誌としては十分に得難い数字です。全科が対象の雑誌なので、眼科雑誌よりも高い値です。その全文のPDFはネット(https://www.jsTAGSe.jst.go.jp/article/tjem/238/4/238_267/_html)からも入手できます。

【このたびその英文抄録が手に入りましたのでそれを再度記載しておきます。】

 この論文では、大脳の第一次視覚領における糖代謝ばかりでなく、フルマゼニルPETでとらえられる脳のその部分の細胞が完全に残っているならばという前提を抑えているところが味噌です。

31-2

○Tohoku J Exp Med. 2016;238(4):267-71.
Improvement of Glucose Metabolism in the Visual Cortex Accompanies Visual Field Recovery in a Patient with Hemianopia. Suzuki Y1, Kiyosawa M, Oda K, Ishiwata K, Ishii K.

Suzuki Y1, Kiyosawa M, Oda K, Ishiwata K, Ishii K.
Improvement of Glucose Metabolism in the Visual Cortex Accompanies Visual Field Recovery in a Patient with Hemianopia.
Tohoku J Exp Med. 2016;238(4):267-71. doi: 10.1620/tjem.238.267.

Abstract(これは翻訳準備中です)

Damage to the visual cortex or the geniculostriatal pathways could cause homonymous visual field (VF) defects at the contralateral side of the lesion. In clinical practice, it is known that the VF defects are gradually recovered over months on the cases. We report a case with recovered homonymous hemianopia following an infarction in the visual cortex by positron emission tomography (PET) with (18)F-fluorodeoxyglucose (FDG) and (11)C-flumazenil (FMZ). A 58-year-old man experienced defect of left VF, and magnetic resonance imaging (MRI) revealed a localized infarction in the right occipital lobe. Goldmann VF perimetry revealed left homonymous hemianopia, but central VF was intact. Three months after the onset of infarction, we measured cerebral glucose metabolism with FDG and FMZ binding using PET. FMZ binding reflects the density of surviving neurons. Moreover, eight months after the onset, FDG-PET scan was performed. Goldmann VF perimetry was also performed at the same times of PET examinations. Decrease of cerebral glucose metabolism in the right anterior striate cortex was observed at three months after onset, while FMZ binding in the same area did not decrease in the patient. At eight months after onset, we observed recovery of VF and improvement of cerebral glucose metabolism in the anterior striate cortex. We presented change of cerebral glucose metabolism using PET accompanying improvement of VF. Evaluation of cerebral glucose metabolism and FMZ binding in the striate cortex is useful for estimating the prognosis of hemianopia caused by organic brain damage.

http://www.ncbi.nlm.nih.gov/pubmed/27039943

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