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Br J Ophthalmol doi:10.1136/bjophthalmol-2014-305809
Alteration of the optic radiations using diffusion-tensor MRI in patients with retinitis pigmentosa
Aya M Tokumaru4,
1Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan
2Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
3Kiyosawa Eye Clinic, Tokyo, Japan
4Department of Diagnostic Radiology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, Tokyo, Japan
Dr Kenji Ishii, Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Sakae-cho 35-2, Itabashi-ku, Tokyo 173-0015, Japan; firstname.lastname@example.org
Received 9 July 2014
Revised 8 January 2015
Accepted 12 January 2015
Published Online First 30 January 2015
Purpose To evaluate alteration of the optic radiation (OR) in patients with retinitis pigmentosa (RP) using fractional anisotropy (FA) measured by diffusion tensor MRI.
Methods We performed MRI and evaluated alteration of the ORs in 17 patients with RP and 27 healthy controls. Regions of interest were placed over the bilateral anterior and posterior areas of the ORs, and we measured the FA value of each region. Visual field (VF) tests were examined in all subjects, and we corrected the residual VF area according to the projection area to the striate cortex. Differences between the FA values of patients and healthy controls were tested. We performed regression analyses between the sum of the corrected VF areas and FA values in the anterior or posterior contralateral ORs in patients with RP. Moreover, we performed regression analyses between the average of FA values of ORs and the average of both eyes of visual acuity in patients with RP.
Results FA values of the bilateral anterior and posterior ORs were lower in patients with RP (anterior right, p=0.012; posterior right, p=0.0004; anterior left, p=0.0008; and posterior left, p=0.0004) compared with those of healthy controls. In patients with RP, significant correlations were observed between average FA values of anterior ORs and average visual acuity (correlation coefficient (r)=−0.54; p=0.025).
Conclusions In patients with RP, alterations may occur not only in the retina but also in the brain.
Categorised in: 糖尿病網膜症・加齢黄斑変性 （網膜疾患）